We have put together a list of words that are similar to VICISSITUDE.

4 Alternative Words Similar to vicissitude

1 Fluctuation Noun      Synonym Words Like Fluctuation
2 Variation Noun      Synonym Words Like Variation
3 Alternation Noun      Synonym Words Like Alternation
4 Interchange Noun      Synonym Words Like Interchange

10 definitions of vicissitude

1 Regular change or succession from one thing to another; alternation; mutual succession; interchange.
2 Irregular change; revolution; mutation.
3 Changing conditions of fortune in one's life; life's ups and downs.
4 mutability in life or nature (especially successive alternation from one condition to another)
5 a variation in circumstances or fortune at different times in your life or in the development of something
6 A change or variation.
7 The quality of being changeable; mutability.
8 One of the sudden or unexpected changes or shifts often encountered in one's life, activities, or surroundings. Often used in the plural. See Synonyms at difficulty.
9 Regular change or succession of one thing to another; alternation.
10 A passing from one state or condition to another; irregular change; revolution; mutation: as, the vicissitudes of fortune.
We get our data from many different dictionaries across the web:
Wordnik, Wiktionary, Century, American Heritage, Gcide